Moreover, the Z-score (a measurement of activation) from IPA suggests that fibrotic changes-related processes in the pulmonary fibrosis idiopathic signaling pathway and hepatic fibrosis signaling pathway are positively upregulated in SENP2 S344A KI MLECs compared to WT MLECs after L-flow (Figure 6A; Supplementary Table S1). This evidence concerns the gene SENP2 and Hepatic fibrosis.