The studies by Staats et al. (2013) with SOD1 transgenic mice and SOD1-knockout mice for β2-microglobulin (β2m), an obligatory subunit of the MHC-I molecule, reinforce that MHC-I is involved in slowing down the progression of ALS: the results show that SOD1-β2m knockout animals present faster disease progression. This evidence concerns the gene HLA-G and amyotrophic lateral sclerosis.