The role of BK in angioedema as the B2BK receptor agonist has been unequivocally established (Hofman et al., 2016; Schmaeir, 2018; Rex et al., 2022; Gailani, 2023) through the increase in vascular permeability, but also desArg9BK, the B1BK receptor agonist, seems to be relevant as these receptors modulate neutrophil trafficking (Araújo et al., 2001). This evidence concerns the gene KNG1 and angioedema.