MTDH and breast cancer: Although the function of miR-217 is not fully established in B-cell lymphomas, the overexpression of miR-217-5p significantly decreased breast cancer cell proliferation, invasion, migration, and suppressed epithelial-to-mesenchymal transition due to the inhibition of the NF-κB signaling pathway by directly targeting metadherin (MTDH) (146) which is also known as astrocyte elevated gene 1 (AEG1) or LYRIC (Lysine Rich CEACAM1) (147).