MGMT and central nervous system cancer: In addition to IDH genotyping, genetic phenotypes and molecular characteristics such as chromosome 1p/19q co-deletion, O-6-methylguanine-DNA methyltransferase (MGMT) methylation, and phosphatase and tensin homologue deleted on chromosome 10 (PTEN) genotyping also have important effects on the prognosis and treatment of gliomas (14).