The first 10 mutated genes in ccRCC patients with high KIFscores were VHL, PBRM1, TTN, SETD2, BAP1, MUC16, MTOR, HMCN1, XIRP2, and PTEN, and the first 10 mutated genes in ccRCC patients with low KIFscores were VHL, PBRM1, TTN, SETD2, MTOR, KDM5C, LRP2, MUC16, ANK3, and DNAH9. The gene discussed is MUC16; the disease is nonpapillary renal cell carcinoma.