With the development of gene sequencing technology, more and more genes, such as signal transducing adaptor protein 1 (STAP1), lysosomal acid lipase (LIPA), ATP binding cassette subfamily 6 member 5 (ABCG and ApoE, have been suggested to be possibly associated with the pathogenesis of FH as well) (Cao et al., 2021). The gene discussed is APOE; the disease is familial hyperaldosteronism.