Familial hypertriglyceridemia is the result of a single gene mutation, usually in the lipoprotein lipase (LPL) or ApoC2 or ApoA5 genes involved in TG metabolism (Willer et al., 2013), and manifests as severe hypertriglyceridemia (TG > 10 mmol/L) with an incidence of about 1 in 1 million. Here, APOA5 is linked to hypertriglyceridemia.