These genes were classified into different biological pathways, including signaling pathways of insulin, neurotrophin, estrogen, ErbB, and GnRH and pathways of chronic myeloid leukemia, ubiquitin mediated proteolysis, spliceosome, melanogenesis, and renal cell carcinoma (Figure 4(d)). Here, EGFR is linked to chronic myelogenous leukemia, BCR-ABL1 positive.