These genes were classified into different biological pathways, including signaling pathways of insulin, neurotrophin, estrogen, ErbB, and GnRH and pathways of chronic myeloid leukemia, ubiquitin mediated proteolysis, spliceosome, melanogenesis, and renal cell carcinoma (Figure 4(d)). This evidence concerns the gene INS and hereditary clear cell renal cell carcinoma.