In our cohort, 82 DEGs were positively correlated with MeCP2 expression levels (hence, upregulated in MDS and downregulated in RTT), and 100 DEGs were negatively correlated with MeCP2 expression (upregulated in RTT and downregulated in MDS) (Additional file 9: Table S6a,b). This evidence concerns the gene MECP2 and myelodysplastic syndrome.