Chromosomal duplications at Xq28 encompassing the MECP2 and IRAK1 genes, leading to their gain of function, cause MECP2 duplication syndrome (MDS), a neurological disorder characterised by intellectual disability (ID), infantile hypotonia, seizures, speech impairment and recurrent respiratory infections [9]. This evidence concerns the gene MECP2 and myelodysplastic syndrome.