However, nearly half of the patients with T2DM who need basal-and-bolus insulin as their treatment strikingly reported inappropriately restricting insulin use against their doctors’ instructions (i.e., deliberately taking less insulin than required), and a greater proportion of body image concern and disordered eating was seen in the patients with T2DM than those with T1DM. This evidence concerns the gene INS and type 1 diabetes mellitus.