UCP1 and obesity due to melanocortin 4 receptor deficiency: In addition, the methyltransferase 3 (METTL3) regulates the expression of PR/SET domain 16 (PRDM16), peroxisome proliferator activated receptor gamma (PPARγ), uncoupling protein 1 (UCP1) transcripts, whose downregulation can impair the maturation of brown adipose tissues, leading to IR and high-fat diet (HFD)-induced obesity [11].