Additionally, CGA diminish body weight and fat deposition which may be related to peroxisome proliferator-activated receptor gamma, coactivator 1α (PGC-1α), and uncoupling Protein 1 (UCP1) in the monosodium glutamate (MSG)-induced obesity mouse model and the oleic acid-induced HepG2 cells [13]. Here, PPARGC1A is linked to obesity due to melanocortin 4 receptor deficiency.