Upregulation of METTL1 demonstrates suppressive effects in teratoma with CC [40, 106] but has considerable pro-oncogenic effects in HCC, ICC, HNSCC, NPC, BC, LC, ESCC, NBL, and glioma [14, 46, 71, 74, 76, 79, 80, 87, 91, 93]. The gene discussed is METTL1; the disease is intrahepatic cholangiocarcinoma.