Through utilizing a human apoptosis antibody array, we identified the upregulation of Caspase8 and sTNF-R1, and downregulation of CD40, HSP60, IGF-I and XIAP in MCM8 knockdown cells, by which may MCM8 regulate the biological behaviours of CRC cells especially cell apoptosis. The gene discussed is CD40; the disease is colorectal carcinoma.