CHSY1 and colorectal carcinoma: As shown in Fig. 5, it was demonstrated that overexpression of MCM8 exhibited strong promotion effects on CRC development through accelerating cell proliferation (Fig. 5A), inhibiting cell apoptosis (Fig. 5B) and enhancing cell mobility (Fig. 5C and D), which could be partially prohibited or even reversed in CHSY1-deficiency cells.