A recent study also reported elevated miR-223 as a negative regulator of Keap1 (both mRNA and protein levels) and upregulated levels of Nrf2, HO-1, SOD1 and SOD2 protein levels in type 2 diabetes mellitus (T2DM) induced human hepatocarcinoma cell line (HepG2) cell lines, thereby mitigating liver injury [30]. This evidence concerns the gene KEAP1 and type 2 diabetes mellitus.