As shown in Fig. 5, upon exposure to P. gingivalis stimulation, the expressions of ferroptosis-promoting genes Acsl4, Ncoa4 and Socs1 were significantly up-regulated and ferroptosis-inhibiting gene Gpx4 was significantly down-regulated in lung single cell suspensions obtained from both healthy mice and ligature-induced periodontitis mice. Here, SOCS1 is linked to periodontitis.