NRG1 and obesity due to melanocortin 4 receptor deficiency: Regarding our findings of the association of reduced NRG-1 with obesity, Wang et al. [59] reported that NRG-1 treatment experimentally, improved glucose tolerance in diabetic mice [60], which further supports enhancing NRG-1 pathway as a promising treatment for insulin resistance besides its role in oxidative metabolism [61, 62].