PIK3CA and cancer: The network relationship between these six signal pathways and target genes was plotted (Additional file 3: Figure S3C), and the figure displayed that KRAS, PIK3CA, PIK3R1, and PRKACA were evident in the pathways in cancer, HTLV-I infection, Viral carcinogenesis, Estrogen signaling pathway, and Progesterone-mediated oocyte maturation.