EGFR and neoplasm: Given the tolerable safety profiles of both amivantamab and lazertinib and the potential for improved anti-tumor activity, the amivantamab and lazertinib regimen was evaluated in the ongoing CHRYSALIS study, with preliminary efficacy assessed in patients with EGFR ex19del or L858R metastatic NSCLC whose disease progressed on osimertinib or another third-generation EGFR TKI but had not received cytotoxic chemotherapy in the metastatic setting (cohort E).