Previous studies have shown that c-MYC directly regulates ornithine decarboxylase 1 (ODC1), spermidine synthase (SRM), and glutaminase (GLS), the upstream genes of polyamine metabolism59,60, its synergistic relationship with polyamine metabolism has been demonstrated in bladder cancer, neuroblastoma, and colorectal cancer61–63. This evidence concerns the gene GLS and neuroblastoma.