First, we compared the difference in mRNA expression between normal and tumor groups in lung adenocarcinoma with CPS1 and SMS genes in the TCGA and GEPIA2 databases, and also validated them in the GEO database (Supplementary Fig. S7A,B), and analyzed the protein expression level of data from CPTAC in the UALCAN database. The gene discussed is SMS; the disease is lung adenocarcinoma.