Notably, there was no difference in tumor infiltration by T cells (CD3+) in the sgMsh2-targeted model (Extended Data Fig. 2d,e) or infiltration by cytotoxic (CD8+), helper (CD4+) or regulatory (CD4+FOXP3+) T cells within tumors (Fig. 2e–g) or whole lungs (Extended Data Fig. 2g,h) in the KPM model at either timepoint. This evidence concerns the gene CD4 and neoplasm.