Our finding that 11,12-EET exhibits high affinity for FABP3 combined with the observation that TPPU-induced synaptic depression is completely blocked by the potent FABP3 inhibitor SBFI-11091 suggests that 11,12-EET transport by FABP3 may underlie the depression of glutamate synapses in CA1 pyramidal neurons. The gene discussed is FABP3; the disease is major depressive disorder.