Interestingly, the most significantly upregulated genes in Ppm1dT/+ AML (Zbed3, Runx3, Marcks, Extl3, Pcbp4, Igf2bp3, Plch1, and Gdf6) were previously associated with AML and cancer progression [52–58]. The gene discussed is IGF2BP3; the disease is acute myeloid leukemia.