Interestingly, the most significantly upregulated genes in Ppm1dT/+ AML (Zbed3, Runx3, Marcks, Extl3, Pcbp4, Igf2bp3, Plch1, and Gdf6) were previously associated with AML and cancer progression [52–58]. This evidence concerns the gene ZBED3 and acute myeloid leukemia.