In conclusion, we analyzed the association between HLA-DRB1 alleles and prognosis in Japanese patients with RA who were starting ABT, TCZ, and TNF inhibitor treatment, and we showed that among SE alleles, the HLA- DRB1*04:05 allele was associated with better outcomes with ABT. The gene discussed is HLA-DRB1; the disease is rheumatoid arthritis.