We further identified that alterations in 3 genes, GID4, POT1, and RAD51B, were enriched in sarcomas with high telomeric content, specifically within soft tissue sarcoma nos for GID4 (Bonferroni-corrected p < 0.01, OR = 3.9 [2.0–7.7]), angiosarcoma samples for POT1 (Bonferroni-corrected p < 0.05, OR = 5.3 [2.0–14.4]), and uterus leiomyosarcoma for RAD51B (Bonferroni-corrected p < 0.01, OR = 20.5 [2.6–146.0], Fig. 1B and Table S2). Here, POT1 is linked to soft tissue sarcoma.