lncRNA growth arrest‐specific transcript 5 has multiple cell functions, including promotion of vascular endothelial growth factor (VEGF)-A, apoptosis (decreasing Bcl/BAX ratio), and pyroptosis.204 In ARPE cells, hyperglycemia downregulates expression of growth arrest‐specific transcript 5, which inhibits ER stress by interacting with sarcoplasmic/ER Ca2+ ATPase 2, which leads to inflammation and BRB injury.188,205 miR-204 directly targets and downregulates sirtuin-1 lysine deacetylase in RPE. This evidence concerns the gene VEGFA and Hyperglycemia.