Nucleotide changes in the oxysterol-binding protein, including c.347A>G, c.450G>T, and c.2351G>A, are found in patients with dry AMD.281 Single-nucleotide polymorphisms in CXCL3 are risk variants for AMD.282 ERp29 deficiency resulting in protein accumulation in CCL2−/−/CX3CR1−/− mouse models might explain the ER stress activation and related AMD.283. The gene discussed is OSBP; the disease is age-related macular degeneration.