Using TUDCA or IRE1α inhibitors can relieve the inflammation induced by the IRE1/NOD2 pathway and NLRP3-induced pyroptosis and apoptosis.383,385 Galectin-3, a 31-kDa chimeric lectin characterized by a binding affinity for β-galactose-containing carbohydrates, can ameliorate the intestinal phenotype of BS via downregulation of ER stress and NLRC4 activation in BS.390 The concrete treatment effect on uveitis needs more investigation. Here, NOD2 is linked to Bloom syndrome.