CHOP increases with age, and XBP1 decreases in human eye tissue.105,106 In the aged human retina, protein aggregates of non-phosphorylated tau and α-synuclein increase substantially, further supporting the presence of protein misfolding and the resulting ER stress.107 In a micro-bead-injected mouse model and a silicon oil-induced ocular hypertension mouse model, the high IOP and RGCs loss are accompanied by CHOP elevation.108. This evidence concerns the gene DDIT3 and ocular hypertension.