ATF4 and Bloom syndrome: A comparison of blood samples from BS patients with those of healthy individuals revealed decreased ER stress-related proteins, such as HSPA8 and GRP78/BiP, but increased CHOP and ATF4, indicating dysregulation of the protein-folding mechanism and ER stress involved in BS pathogenesis.388 In acute anterior uveitis patients, ER stress increases proinflammatory cytokine levels.389