MANF and open-angle glaucoma: Utilizing neurotrophins can directly support neuron regeneration, restoring their function.180 Furthermore, considering the reduced content of neurotrophic factors, which are correlated with ER stress, applying BDNF and mesencephalic astrocyte derived neurotrophic factor (MANF) can inhibit the upregulation of CHOP and prevent RGCs apoptosis.117,120 Also, recombinant human NGF prevents RGCs loss and was shown to be safe and effective in a phase 1b randomized controlled study of POAG patients.181