Mitochondrial ROS quencher MitoQ can reduce BiP and GADD153 expression in Slc4a11 KO cells and mice.416 It has been successfully demonstrated that the coexpression of R125H and SLC4A11 facilitates mutant protein transportation to the cell membrane without affecting water flux.433 Antioxidative therapy like N-acetylcysteine can relieve ER stress.434 High-throughput assays allow scientists to screen drugs like glafenine and perhaps other non-steroidal anti-inflammatory drugs for helping SLC4A11 properly fold,435 and could also find more potential therapeutics for corneal diseases. Here, SLC4A11 is linked to corneal disorder.