Subretinal injection of CNG cDNA packaged with AAV recovers cone function and vision.355 In late-stage CNGB3-achromatopsia, AAV-delivered CNGB3 cDNA and neurotrophic factors CNTF by subretinal injection to help restore cone function.356 CRISPR/Cas9 can be used in the ablation of mutated genes such as CNG, PDE6, and ATF6. This evidence concerns the gene ATF6 and achromatopsia.