OPTN and open-angle glaucoma: OPTN is an adapter protein mainly expressed in the cytoplasm and the autophagy receptor of the cell,76,84 whose mutation results in autophagy dysfunction, impaired signal transduction, and protein accumulation.85,86 OPTN mutations including E50K, R545Q, M98K, and 691_692insAG can be found in POAG with high IOP and normal IOP.87 TBK1 is associated with the autosomal dominant inheritance of normal glaucoma.