Collectively, this study demonstrated that pro-inflammation secretion of DCs driven by the CXCR1 played an inflammation-promoting role in inflammation and autoimmunity diseases, and a mechanism was further revealed whereby CXCR1 promoted IL-6 and IL-12p70 production via CXCL5/CXCR1/HIF-1α positively feedback loop. This evidence concerns the gene CXCL5 and autoimmune disease.