Consistently, mice lacking CXCR1 were protected from LPS-induced ARDS by exhibiting reduced CD4+ T cell percentage (Fig. 6F), the proportion of IFN-γ+ and IL-17A+ (Fig. 6G) and the mRNA levels of Il6, Il12a, Cxcl5, and Hif1α in lung tissue (Fig. 6H). Here, CD4 is linked to acute respiratory distress syndrome.