Notably, this skipped isoform of MPRIP was identified as a MAPK and RHO GTPase pathway interactor and was highly abundant in metastatic PDAC, accompanied by worse survival of PDAC patients.1 This highlights the importance of a functional splicing machinery in preventing metastatic spread since only one mis-spliced protein can have tremendous effects on the tumor integrity.1 As RBFOX2loss-MPRIPskip–RHO axis is critical for metastatic spread, the authors employed two distinct pharmacological inhibitors such as MBQ167 and azathioprine against RHO GTPase pathways. The gene discussed is RHO; the disease is neoplasm.