Among those, cancer stemness-associated genes were identified, including LINGO2, PAK3, JADE3, MLLT3, SRPK1, HIST1H2BF, CTBP2, TARBP2, CREBBP, COL6A1, and FAM83F. Genomic distribution analysis revealed that 48.7% of the cooccupied DNA-binding sites are located within the gene body, 38.1% are distal intergenic, and only 9.5% are located at gene promoters (Fig. 5m). This evidence concerns the gene JADE3 and cancer.