KMT2A and pachyonychia congenita: Collectively, our data from the small molecule compound screening in PC cells and in vitro cell-based functional assays involving the inhibition of the HMT activity of KMT2A in PCSCs indicate that KMT2A plays an important epigenetic role in regulating PCSC stemness and survival, which renders this epigenetic modulating enzyme an ideal candidate for further investigation.