Silencing of MDIG in HCC cell lines significantly promoted the enrichment of H3K9me3 at the promoter regions of CDC6, which in turn led to decreased CDC6 expression and repressive cell-cycle progression.16 Furthermore, emerging evidence demonstrates that epigenetic code is embedded in quiescent tissue to dictate the gene expression pattern required for regeneration.23 Thus, it is plausible that as an epigenetic modifier acting on histone, MDIG may be involved in regulating liver regeneration, which warrants our investigation. Here, RIOX2 is linked to hepatocellular carcinoma.