Similar to metaplastic carcinomas that show EMT characteristics with enhanced mesenchymal gene expression and claudin low phenotype, PZP cells expressed higher levels of EMT-associated genes ZEB1, ZEB2, SNAI1 and TWIST1 but lower levels of E-Cadherin and Claudin-7 (CLDN7) compared to epithelial cells. The gene discussed is TWIST1; the disease is carcinoma.