As indicated in Figure 3A–3C, ascites proinflammatory cytokines IL-1β, IL-6, TNF-α were increased in model mice, but were significantly reduced following EFL1 or DOX administration, which demonstrates that EFL1 is able to decrease the generation of proinflammatory cytokines caused by breast cancer liver metastasis. The gene discussed is TNF; the disease is breast carcinoma.