CD8A and infection: Interestingly, a study by Xu et al. challenges previous studies which demonstrated autophagy activation in response to TCR stimulation: In transgenic P14 mice infected with LCMV, levels of LC3B and p62 protein were increased in CD8+ T cells five days after infection, while autophagic flux was highest eight days after infection, arguing for inhibition of autophagy in earlier stages of antigen-induced T cell activation [204].