By analyzing the data of 116 cirrhotic HCC versus 158 patients with cirrhosis, we found that the median values for AFP, DCP (PIVKA-II), and AFP-L3 were significantly higher in patients with HCC than in those with cirrhosis, especially in HCC patients with BCLC stage B, C and D (Figure 1). Here, ACE is linked to hepatocellular carcinoma.