Age was associated with HCC risk in the alcohol sub-cohort, with significant p values (p = 0.02, p = 0.01, and p = 0.009) (Supplemental Table 4, http://links.lww.com/HC9/A511) at each time point, and the blood parameters AST and alanine aminotransferase were risk factors, p < 0.05. The gene discussed is GPT; the disease is hepatocellular carcinoma.