Fig. 3 displays levels of counter-regulatory hormones at the end of each clamp stage in relation to individual mean glucose levels during the preceding 20 minutes. Glucagon levels were higher in the normo-hyperglycemic range in T2D vs ND (Fig. 3A). In contrast, there was no clear group difference during hypoglycemia. Cortisol and ACTH did not differ between the groups (Fig. 3B and 3C). GH was generally lower in T2D vs ND (Fig. 3D). Here, POMC is linked to type 2 diabetes mellitus.