While C-peptide AUC did not differ between the groups in both clamps, C-peptide ΔAUC was lower in T2D vs ND in the hyperglycemic clamp but not in the hypoglycemic clamp (Fig. 1E and 1F), in congruency with the insulin trajectory and indicative of beta-cell dysfunction. The gene discussed is INS; the disease is type 2 diabetes mellitus.