POMC and type 2 diabetes mellitus: Disturbances in the hypothalamic-pituitary-adrenal (HPA) axis, wherein pituitary release of adrenocorticotropic hormone (ACTH) stimulates adrenal secretion of cortisol, have also been implicated in the development of T2D, and this has also been proposed to play a role in the association between psychiatric conditions and T2D (9).