However, there was no significant difference in the number of migration and invasion cells between the control+SF1670 group and the sh-RNA KIF18A+SF1670 group (Figure 6), which indicated that KIF18A can increase the migration and invasion of CRC cells by inhibiting PTEN to promote the activation of PI3K/Akt signaling pathway (Figure 7). This evidence concerns the gene PTEN and colorectal carcinoma.