AKT1 and colorectal carcinoma: However, there was no significant difference in the number of migration and invasion cells between the control+SF1670 group and the sh-RNA KIF18A+SF1670 group (Figure 6), which indicated that KIF18A can increase the migration and invasion of CRC cells by inhibiting PTEN to promote the activation of PI3K/Akt signaling pathway (Figure 7).