Bulk RNA sequencing indicated that the main aspects of the innate microglia and astroglial cellular transcriptomic responses to amyloid plaques are maintained in the Rag2-/-/AppNL-G-F immunodeficient mouse compared with a previously characterized nonimmunosuppressed amyloid mouse (APP/PS1) (12, 13) (Fig. 1B) [coefficient of determination (R2) = 0.81 for differentially expressed genes]. The gene discussed is RAG2; the disease is amyloidosis.