We tested for associations between ABO genotype and severe malaria, including the specific severe malaria syndromes cerebral malaria (CM), severe malarial anaemia (SMA) and respiratory distress (RD), and malaria-specific mortality using a logistic regression model both with, and without, adjustment for the confounders HbS, α+thalassaemia, gender, and ethnicity. The gene discussed is ABO; the disease is malaria.