HLA-C and viral infectious disease: Of interest is the observation that 2 of the highest allele frequencies for the three classical HLA class I genes, specifically HLA-C*07 (23 patients including 8 homozygotes; 25% of the total cohort) and HLA-B*35 (30 patients including 3 homozygotes; 32.6% of the total cohort) are alleles that have been associated with different viral infections [31, 32].