GBP2 and infection: Indeed, many host antiviral factors, such as GBP2/5 [55,56], protease-activated receptor 1 (PAR1) [62–64], α-SNAP [57], and possibly lectin galactoside-binding soluble 3 binding protein (LGALS3BP/90K) [65,66] targeted furin to restrict infection by a group of viruses, demonstrating a conserved cellular type-II CTI antiviral mode.