The z-MARCH8 then targeted cellular TANK-binding kinase 1 (TBK1) and mediator of IRF3 activator (MITA) for intracellular degradation, which down-regulated IFN responses and thereby facilitated SVCV and grass carp reovirus (GCRV) infection, consistent with the negative regulation of MARCH8 on innate immunity signaling, as discussed above [52]. This evidence concerns the gene TBK1 and infection.