In the final fitted multivariate model, lower hazard rates of OI were associated with age at first ART 2–14 years compared to <2 years (lowest asHR for 10–14 years 0.48 95% CI 0.28–0.82), current CD4 ≥200 cells/μl compared to <200 cells/μl (lowest asHR for 350–499 cells/μl 0.19 95% CI 0.10–0.37 and ≥500 cells/μl 0.19 95% CI 0.12–0.31), and receiving ART between 2017 and 2020 compared with between 2011 and 2013 (asHR 0.46 95% CI 0.22–0.97). This evidence concerns the gene CD4 and osteogenesis imperfecta.