Interestingly and worth mentioning that, according to ChIP-seq database, both H3K4me3 and WDR5 were found to bind to the ABCG2 promoter region in CRC cells, and the binding position just includes the segments of −261 to −141, which was similarly bound by TOX3 within ABCG2 promoter (Fig 4B). Here, TOX3 is linked to colorectal carcinoma.