Since TOX3-WDR5/ABCG2 signaling axis has been found to play a vital role in cCSCs expansion and drug resistance according to our in vitro and in vivo research, and cancer stem-like traits serve as a molecular phenotype, which is closely related to tumor metastasis, spread and the poor clinicopathological characteristics, further exploring the clinical implications of this signaling axis seems necessary. The gene discussed is ABCG2; the disease is neoplasm.