Given that as a drug-resistant molecule, ABCG2 is involved in single-drug and multidrug resistance in different types of tumors, we supposed that TOX3 similarly promotes drug resistance in CRC based on its regulation on ABCG2 and the contribution of TOX3/ABCG2 signaling axis in maintaining cancer cell stem-like traits. The gene discussed is TOX3; the disease is colorectal carcinoma.