Based on our current results, we could only preliminarily conclude that TOX3 was involved in the establishment and maintenance of the stem-like traits of CRC cells mainly by facilitating the transcription of ABCG2 via recruiting WDR5 and its subsequent promotion on the tri-methylation of H3K4 at ABCG2 promoter region. This evidence concerns the gene WDR5 and colorectal carcinoma.