Furthermore, LDA in mice also indicated that TOX3 knockdown improved tumor growth inhibition caused by oxaliplatin, while ABCG2 overexpression abolished such decrease in cCSCs expansion triggered by TOX3 knockdown upon oxaliplatin treatment compared with the control group (Fig 3D and 3E), and the same results were obtained when primary cells were digested from xenografts and used for spheroid formation assay, clonogenicity, and CSC frequency analyses (Figs 3F, 3G and S4E). The gene discussed is ABCG2; the disease is neoplasm.