WDR5 and cancer: Since TOX3-WDR5/ABCG2 signaling axis has been found to play a vital role in cCSCs expansion and drug resistance according to our in vitro and in vivo research, and cancer stem-like traits serve as a molecular phenotype, which is closely related to tumor metastasis, spread and the poor clinicopathological characteristics, further exploring the clinical implications of this signaling axis seems necessary.