Among the different annotated pathways identified, AMPK signaling (23), cell cycle (24), TGF-β signaling (25), and O-glycan biosynthesis (26) were prominent (Figure 7 and Supplemental Table 3), supporting a role for perturbation of these signaling pathways central to endothelial-mesenchymal transition/fibrosis in renal dysfunction in HFpEF. The gene discussed is TGFB1; the disease is Abnormal renal physiology.