ATP7B and Hepatic fibrosis: Liver pathology showed areas of advanced fibrosis and intense inflammation, together with liver regeneration and biliary proliferation in Atp7b–/– mice treated with the control vector, whereas moderate liver fibrosis and inflammation were observed in mice injected with AAV8-Alb-ATP7BΔ1-4 (Supplemental Figure 3D) that also showed a concomitant significant decrease in hepatic and urinary copper levels compared with AAV8-GFP–treated livers (Figure 3, C and D).