Following ZIKV infection of hBMECs, we found that both IFNβ and IFNλ1 were transcriptionally induced 1–3 dpi (Fig. 1B and C), but we failed to detect IFNβ or IFNλ secretion into cell supernatants by enzyme-linked immunosorbent assay (ELISA) (Fig. 1D and E). This evidence concerns the gene IFNL1 and Zika virus infectious disease.