hBMECs secrete type I (IFNβ) and type III (IFNλ) IFNs; however, as hBMECs lack IFNλRs and fail to respond to IFNλ, ZIKV infection of hBMECs is only restricted by type I IFN pre-treatment. Here, IFNB1 is linked to Zika virus infectious disease.