Collectively, IFN induction without IFN secretion following ZIKV infection was noted in immune cells, where TTP expression in response to LPS is well characterized, and mirrored our own observations of ZIKV inhibiting IFN secretion in hBMECs at a translational level (9, 37, 39, 40). This evidence concerns the gene ZFP36 and Zika virus infectious disease.