While most studies evaluate IFN transcripts as surrogates for IFN expression, a discrepancy between IFNβ/IFNλ induction and secretion has also been reported following ZIKV infection of dendritic cells, peripheral blood mononuclear cells, fetal neural progenitor cells, and placental macrophages (9, 37, 39, 40). This evidence concerns the gene IFNA1 and Zika virus infectious disease.