When PCNSL and PTL were grouped as primary large B‐cell lymphoma of immune‐privileged tissue, the genes showing statistically significant differences in DLBCL NOS, immune‐privileged sites, and PMLBL were STAT6, MYD88L265P, PIM1, CD79B, SOCS1, TNFAIP3, PTPN1, CIITA, GNA13, and B2M in SNV, and CD274 gain, PDCD1LG2 gain, CDKN2A loss, and CDKN2B loss in CNV (Figure 1). This evidence concerns the gene CDKN2A and primary central nervous system lymphoma.