SPP1 and atherosclerosis: Interestingly, Trem2+ LAMs expressing Spp1 showed a transcriptional profile similar to osteoclasts during advanced stages of murine atherosclerosis (Cochain et al., 2018), and human multinucleated giant cells express MAM markers such as SPP1, MMP9, CHI3L1 in granulomatous slack skin (Feng et al., 2023).