Furthermore, when compared with healthy control tissue, the proportions of SPP1+ macrophages were consistently increased in cirrhotic/NASH liver (Figure 1A), IPF/SSC lung (Figure 1B), ICM/DCM heart (Figure 1C), keloid/SSC skin (Figure 1D), endometriosis uterus (Figure 1E), and CKD/AKI kidney (Figure 1F). Here, SPP1 is linked to metabolic dysfunction-associated steatohepatitis.