SPP1 and neoplasm: Furthermore, SPP1+ SAMs share an overlapping transcriptome with TREM2+ tumor-associated macrophages (TAMs) (Mulder et al., 2021), lipid-associated macrophages (LAMs) (Jaitin et al., 2019), and disease-associated microglia (DAM) (Keren-Shaul et al., 2017; Silvin et al., 2022) – hence lack specific functionality for tissue fibrosis.