SPP1 and Hepatic fibrosis: Importantly, SPP1+ macrophages (also termed as scar-associated macrophages [SAMs], initially described in hepatic fibrosis [Fallowfield et al., 2007] and further refined at a single-cell level in cirrhotic liver [Ramachandran et al., 2019]) have been described as pro-fibrotic cells in human pulmonary and hepatic fibrosis (Morse et al., 2019; Ramachandran et al., 2019; Reyfman et al., 2019; Fabre et al., 2023).