The accumulation of SMC_C1 (SOCS3+ ACTA2+) in the group of OCA (Figure 4G and 4H; Figure S6) and EC_C1 (DARC+ CD31+) in the group of atherosclerosis (Figure 4I and 4J; Figure S6) was further validated using pathological staining. Here, ACTA2 is linked to atherosclerosis.