Considering FAP was the main fibrosis-producing cell type among the cellular population in PVAT, we thus performed the receptor-ligand pair analysis between Ma_3 and 7 FAP subclusters and identified several enhanced interactions like SPP1-CD44 and SPP1-integrin (ITGAV [integrin subunit alpha V], ITGB5 [integrin subunit beta 5], and ITGB1 [integrin subunit beta 1]) in atherosclerosis (Figure 6F). This evidence concerns the gene ITGB5 and atherosclerosis.