The largest spatial transcriptomics dataset for IDH-Mut tumors was generated by Kuchroo et al. using the 10x Genomics Visium platform and includes 10 IDH-Mut astrocytomas across WHO grades II–IV.59 Through a novel ligand-receptor simulation analysis, they enforced the significance of the previously established SPP1-CD44 signaling axis in glioma and identified that genes related to hypoxia regulation and antigen presentation are directly associated with this ligand-receptor interaction.59 This evidence concerns the gene IDH1 and astrocytoma (excluding glioblastoma).