Many existing studies focus on isocitrate dehydrogenase (IDH)-wild type (WT) glioblastoma, the most common form of high-grade glioma, with many of the seminal studies and single-cell atlases specifically excluding cases with mutations in IDH or core histone proteins.5,10,11 Notably, the epigenomic features and unique microenvironmental landscapes (eg, the near-complete paucity of lymphocytes) suggest that high-dimensional profiling with multiomic technologies is aptly suited to study such tumors. Here, IDH1 is linked to central nervous system cancer.