SMARCA4 and central nervous system cancer: In accordance with this principle, Panditharatna et al. identified via a CRISPR screen that OPC-like GSCs specifically maintain H3K27M-Mut glioma via the SMARCA4 gene regulatory network and the BRG1-BAF complex.65 SMARCA4 or BRG1-directed therapy depleted the OPC-like cell population, increased AC-like differentiation, and improved survival in a mouse model.