A single study thus far, by Ren et al., integrates spatial profiling for IDH-WT (n = 3), IDH-Mut (n = 2), and H3K27M-Mut (n = 5) glioma.61 They applied 10x Genomics Visium spatial transcriptomics and identified four spatially defined gene expression modules conserved across samples representing hypoxic, vascular, invasive, and tumor core niches. Here, IDH1 is linked to central nervous system cancer.