A recent single-cell multiomic analysis by Wei et al. suggested that both IDH-A and IDH-O gliomas resemble early stages of the oligodendrocyte lineage with a differentiation block due to hypermethylation and suppression of essential regulators of the myelination program.30 This analysis further elucidates the fundamental mechanistic role of IDH mutations across IDH-Mut astrocytomas and oligodendrogliomas and motivates a potential differentiation therapy approach for IDH-Mut glioma. Here, IDH1 is linked to glioma.