H3K27M-mutant gliomas were initially profiled at the single-cell level by Filbin et al., who identified a similar trajectory to that of IDH-Mut glioma involving proliferating stem cell-like cells which self-renew and differentiate into AC-like and OC-like cells (n = 6 patients).33 Notably, these studies inferred that the cell of origin/progenitor state in H3K27M-Mut glioma more closely resembled oligodendrocyte progenitor cells (OPCs), while IDH-Mut glioma progenitors resembled neural progenitor cells. This evidence concerns the gene IDH1 and central nervous system cancer.