Notably, while both tumor types shared a similar composition of infiltrating T cell subsets, both CD4+ and CD8+ T cell populations were greater in number and had greater cytotoxicity, interferon, and cellular stress programs in IDH-WT glioma.49 Importantly, their key finding that the CD161 receptor inhibits T cell-mediated killing of glioma is relevant independent of IDH status. This evidence concerns the gene CD4 and central nervous system cancer.