IDH1 and neoplasm: A single study thus far, by Ren et al., integrates spatial profiling for IDH-WT (n = 3), IDH-Mut (n = 2), and H3K27M-Mut (n = 5) glioma.61 They applied 10x Genomics Visium spatial transcriptomics and identified four spatially defined gene expression modules conserved across samples representing hypoxic, vascular, invasive, and tumor core niches.