IDH1 and central nervous system cancer: Lastly, although less frequently implemented, spatial metabolomics via mass spectrometry holds the potential to identify metabolic niches with unique vulnerabilities, as demonstrated in IDH-WT glioma, where hypoxic niches were associated with increased genomic instability.52 This technique was applied to IDH-Mut gliomas by Kampa et al. with a cohort of 25 IDH-WT and 6 IDH-Mut gliomas, suggesting that IDH-Mut gliomas possess more perturbations in stromal metabolism compared to IDH-WT gliomas.62