Lastly, following the seminal work by Venkatesh et al. demonstrating that glioma cell synaptic integration promotes tumor progression,26 a recent analysis of an integrated scRNA-seq dataset of 4 IDH-WT and 3 IDH-Mut tumors suggests that IDH-Mut tumors harbor unique GABAergic neuron-like neoplastic cells which are marked by SOX11.27 Functional validation using a patch-clamp demonstrated that these cells uniquely exhibited neurophysiological properties. This evidence concerns the gene IDH1 and central nervous system cancer.